The bark is the part of the tree traditionally used in northeastern Brazil in a psychoactive decoction also called Jurema or Yurema. Analogously, the traditional Western Amazonian sacrament Ayahuasca is brewed from indigenous ayahuasca vines. Powdered tepezcohuite bark contains large amounts (16%) of tannins, which act as an astringent, making the skin stop bleeding. This helps protect the body from infection, while the skin builds new protective tissue. Extensive research has been performed in labs in Mexico, Canada and the United Kingdom. It is now used in commercial hair and skin products that claim to rejuvenate skin. The bark is known to be rich in tannins, saponins, alkaloids, lipids, phytosterols, glucosides, xylose, rhamnose, arabinose, lupeol, methoxychalcones and kukulkanins. In vitro studies have shown three times more bacteriocidal activity on bacterial cultures than streptomycin, and it works to some degree in vivo.